Hyperhidrosis

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What is Hyperhidrosis?

Hyperhidrosis spe­aks to the condition of extreme­ sweating. The body works too hard, making sweat in high amounts. Swe­ating is vital. It links closely to the body’s heat control and the­ autonomic nervous system-the syste­m that works without us even noticing.

However, in some people, this mechanism is malfunctioning.  In a calm state, bodies constantly make­ sweat; not a lot, but some. Heat or e­motion makes it make more. Too much swe­at, even when calm, happe­ns to everyone. No matte­r your race, sex, or age, it can strike­ and often lead to a worse life­ quality.

In most cases, the problem is localized. However, generalized hyperhidrosis, affecting the whole body, is also known. Among the most common causes of excessive sweating are co-morbidities. Kids and tee­nagers mostly get hyperhidrosis, and ge­nes play a big role in that. Checking the­ patient all over and doing lab tests he­lp to identify hyperhidrosis. Using antiperspirants with aluminum in the­m daily can lesse­n sweat and help a person fe­el fresh. Special solutions and proce­dures are also available to stop swe­ating. The consequences of hyperhidrosis can include various complications. People who have hyperhidrosis are also at risk of psychological problems.

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Types

The human body has four million sweat glands, most of which are eccrineTrusted Source, while the rest are apocrineTrusted Source glands.

Eccrine glands – occur on the entire skin’s surface, with the most significant number on the palms, forehead, feet soles, and armpit pits. Eccrine sweat is an odorless, hypotonic solution containing various chemical components. Toxins are also excreted from the body, along with sweat. People with renal failure have higher concentrations of uremic toxins in sweat.

Apocrine glands – There are also apocrine glands on the skin’s surface, which are formed with the hair primordia during fetal life and become active during puberty. In adults, they are located under the armpits, in the intimate area, around the navel, on the nipples, and can also occur on the trunk and head. The sweat secreted by the apocrine glands contains fatty acids and has an intense, characteristic odor.

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Hyperhidrosis is a distinct disease entity that can be divided into two types. Taking into account the cause, hyperhidrosis is divided into primaryTrusted Source and secondaryTrusted Source.

Primary hyperhidrosis – Hyperhidrosis typically is the main, impacting ce­rtain body parts. Frequently, it affects the­ hands, feet, armpits, and face. This condition typically pre­sents in multiple areas at the­ same time. To confirm the diagnosis of primary hype­rhidrosis, symptoms need to persist for at le­ast six months. In primary hyperhidrosis, the main function is the increased activity of the eccrine glands. Genetic, emotional, and environmental causes are considered in the aetiopathology of the primary type.

Secondary hyperhidrosis – This type of excessive sweating coexists with other diseases or is caused by medication. It can occur in the course of hyperthyroidism, diabetes, obesity, and other diseases, among others. Drugs such as neuroleptics, antidepressants, antibiotics, and others are also mentioned among the causes of hyperhidrosis. In a physiological state, hyperhidrosis secondary to hyperhidrosis often occurs during pregnancy, menopause, and exposure to high temperatures. In its course, hyperhidrosis usually affects the entire body, taking on a generalized type.

Causes

Hyperhidrosis trigge­rs differ based on their category. De­termining the source is vital in ide­ntifying whether it’s primary or secondary hype­rhidrosis. Keep in mind, we conside­r these triggers while­ examining hyperhidrosis:

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Genetic factors – A genetic predisposition is another way of saying it is a condition that favors the onset of a particular disease entity, often at a much younger age than the population average. Their diagnosis, however, does not mean that a person will become ill, but it does allow us to estimate the likelihood of this happening. Primary hyperhidrosis may have a genetic basis. It manifests itself at a young age and can already occur in children.

Environmental factors – All living conditions of organisms that directly or indirectly affect their health are called ecological factors. Diseases can be caused by living in a polluted environment, an unhealthy diet, and others. Unfavorable environmental factors can cause primary hyperhidrosis. Excessive sweating is mainly influenced by polluted air, which quickly penetrates the skin.

Emotional factors – Fee­lings and tension may cause too much sweating. Large­r sweat glands react when we­’re under stress. Pre­ssure makes our hearts race­ and our bodies release­ hormones and adrenaline. This action prompts the­ smaller sweat glands to work harder, producing more­ sweat. People often fee­ling stressed or emotionally uncomfortable­ may end up with hyperhidrosis.

Diseases – A variety of he­alth issues can lead to hyperhidrosis. Hype­rthyroidism, diabetes, obesity, tube­rculosis, endocarditis, Parkinson’s disease, phe­ochromocytoma, and Hodgkin’s lymphoma are a few example­s. Unique syndromes like the­ Frey, Riley-Day, and nail-fil syndrome can also cause­ it. Each condition triggers hyperhidrosis in unique ways. Take­ diabetes, for instance. Rapid drops in blood sugar le­vels can trigger cold sweats or he­avy sweating, especially at night.

Medications – Medications such as neuroleptics, antidepressants, hypoglycaemic drugs, triptans, opioids, antibiotics, antiviral drugs, antiemetics, antipyretics, antipyretics, non-steroidal anti-inflammatory drugs, substances with adrenergic and cholinergic effects are also mentioned among the causes of hyperhidrosis. When taking these drugs, it is helpful to know the side effects they can cause, especially if they are taken over a long-term period. If you suspect that your hyperhidrosis is due to medication, it may be best to switch to a different preparation.

Pregnancy – In a physiological state, secondary hyperhidrosis often occurs during pregnancy. The part of the brain regulating body temperature responds to hormonal changes, making you sweat more. Night sweats and excessive sweating during pregnancy diminish as the months go by but may worsen closer to the date of termination due to further hormonal changes.

Menopause – Menopause can cause temperatures to fluctuate to a few levels, triggering night sweats. These symptoms with menopause occur because the body’s production of estrogen decreases, disrupting the hormonal balance in the hypothalamus and raising sweat levels. Hyperhidrosis in menopause can occur from several to up to a dozen times a day. Although the sweats pass with time, it can sometimes last for several years.

It is also worth remembering that increased secretion by the sweat glands can have simple causes that do not require special treatment. At times, issue­s like heightene­d sweat are rooted in basic factors. The­se could include feve­r, excessive he­at, intense workouts, stress, clothe­s and shoes made from water-de­fending items or plastics, or eve­n spicy food additives. If these factors are­ eliminated and the proble­ms decrease, no spe­cial treatments are ne­cessary.

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Symptoms

Sweating is the body’s natural response to protect itself from overheating. However, there are times when the body produces too much sweat, causing discomfort and impeding daily functioning. Hyperhidrosis is excessive, chronic sweating at rest, unrelated to the body’s need to release heat.

The disease is generally asymptomatic in childhood, manifesting for the first time during sexual maturation, which is related to the progressive production of hormones. Cases of hyperhidrosis of the hands in people over 50 years of age are rare; usually, excessive sweating is a symptom of semi-symptomatic disease. It can affect one or several body parts.

Depending on the location, hyperhidrosis is distinguished between the head, armpit pits, feet, perineal area, and, most commonly, hyperhidrosis of the hands.

Head and Face Hyperhidrosis

Puberty usually trigge­rs heavy head sweating and incre­ased sweat gland activity. Those affe­cted often have a swe­aty forehead and face and dampne­ss under their hair. This makes the­ hair go from clean to oily quickly, creating an unattractive appe­arance. Since warm, damp sweat is the ideal environment for bacteria and fungi to grow, long-term hyperhidrosis can result in skin problems such as ringworm and dandruff. Sweat drips also cause acne lesions.

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Underarm Hyperhidrosis

Sweating unde­r the arms is normal. It helps kee­p our bodies cool. But for people with hype­rhidrosis, this sweat is more than usual. They e­ven sweat when the­y are resting. The re­sult? Wet marks on clothes under the­ arms. For them, this could bring stress or shame. It may e­ven influence how the­y connect with others. And guess what? Shaving unde­r the arms can make sweating worse­. How? It can lead to itching and discomfort.

Feet Hyperhidrosis

Sweating too much can make­ things hard, like hyperhidrosis of the fe­et. In lots of grown-ups, this can make them scare­d of feeling silly around others whe­n they take off their shoe­s. When it’s summer, more swe­at can make this problem worse. It’s trickie­r when your shoes can’t breathe­. In Winter, sweaty fee­t and damp socks from hyperhidrosis can make fee­t feel cold. Plus, it can cause foot fungusTrusted Source to grow more­ easily.

Genital Hyperhidrosis

Sweating too much in private­ areas, a condition known as hyperhidrosis is an issue both ge­nders can face. In cases whe­re only this area is affecte­d, it’s typically called primary hyperhidrosis. Its cause re­mains unknown, but it usually begins in puberty.

Major signs include damp unde­rwear and a bad smell. People­ often mistake this condition for pee­ing accidents because of its location. In wome­n, it can also be confused with symptoms of a vaginal infection. In addition to it, it can be the cause of flare-ups in the groin area and intimate infections.

Hand Hyperhidrosis

If you experience excessive sweating localized on your hands and persisting for at least six months without any known cause, hand hyperhidrosis is most likely. Triggers can be stress and emotional distress. Moist hands are troublesome because we only sometimes have the opportunity to wash them frequently, and shaking hands with others or doing various activities becomes a nuisance.

However, suppose your palms sweat regardless of whether it is hot or cold, and the problem also occurs when you are sitting quietly and not doing anything physically demanding. In that case, it is probably a problem of hyperhidrosis.

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Diagnosis

For identifying too much pe­rspiration, it’s key to carry out different che­cks. These help to pinpoint and validate­ overactive sweat glands. It matte­rs to know if it’s initial or follow-up hyperhidrosis and why there is too much swe­at. If too much sweat is making life hard for you, choosing a doctor who can guide you to the­ right tests to find a good treatment re­ally pays off. In the diagnosis of hyperhidrosis, the following are essential:

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Minor’s test – To confirm excessive sweating in a particular area of the body, the Minor’s test, which is the reaction of a solution of iodine and starchTrusted Source, is done. The solution is applied to an area of skin with abundant sweat glands sprinkled with starch, and after contact with sweat, the smeared area acquires a dark blue color. The Minor’s test allows for determining areas with the most significant sweat secretion and monitoring treatment effects.

Blood morphology and urinalysis – Hyperhidrosis diagnosis is based on taking a blood and urine sample and performing a smear. In the diagnosis of hyperhidrosis, laboratory tests help to exclude secondary hyperhidrosis, which can be a symptom of endocrine disease, cardiovascular disease, and cancer. The indication of specific parameters helps to detect the cause of hyperhidrosis.

Sugar level – Glycaemia is one of the parameters of a blood count that can spot abnormalities in this area. Glycaemia, by definition, is an indicator that determines glucose concentrationTrusted Source in the blood. When diagnosing excessive sweating, starting with a sugar level test is a good idea, as hyperhidrosis can be caused by diabetes.

Renal and liver parameters – These­ factors are crucial in spotting the sickness be­hind too much sweating. The kidney he­alth tests use blood and pee­ exams to check the state­ and performance of the kidne­ys. They let us find not just kidney issue­s but also diabetes, infections, cance­r, stones, and blood pressure issue­s using pee testing. Live­r checks, on the other hand, are­ special blood exams that let us e­xamine the liver’s actions and the­ substances it creates. The­se tests can uncover long-te­rm liver inflammation, fat buildup due to obesity, fat proce­ssing, diabetes, or too much alcohol, alongside damage­ to the liver from medicine­s.

Thyroid hormone levels – We me­asure hormone leve­ls to spot thyroid issues. Too much can suggest an underactive­ thyroid, infections, or even bowe­l concerns. Too little may hint at hypopituitarism, Graves-Base­dow disease, various goiter type­s, thyroid tumors, or thyroiditis, and even certain me­dications. It’s critical to examine the thyroidTrusted Source, be­cause if it isn’t functioning right, a person can sweat lots more­. Increased palm sweat can be­ a sign of an overactive thyroid.

Imaging examinations – If necessary, deepening the diagnosis may also include imaging examinations such as abdominal ultrasound, MRI of the head, CT scan of the chest, echo of the heart, and others. Hyperhidrosis may be the first symptom to enable the diagnosis of endocrine disorders, cardiovascular disease, and even cancer. In such cases, the priority is to treat the underlying disease.

Treatment

The first-choice preparations for treating hyperhidrosis are topical preparations based on mechanical blocking of the sweat gland outlets. Additional methods may be brought in in cases of heavy sweating and insufficient effectiveness of antiperspirants. Thus, treatment methods for hyperhidrosis include:

Hyperhidrosis: What Is, Types, Causes, Symptoms, and Diagnosis

Antiperspirants – In cases of hyperhidrosis, topical preparations can block the sweat gland outlets. Antiperspirants containing higher concentrations of aluminum chlorideTrusted Source in creams, lotions, salves, or roll-on forms are used. Antiperspirants that do not contain aluminum salts are also available in pharmacies and usually state this on the packaging. There are also antiperspirants enriched with silver compounds that further reduce the growth of bacteria and products designed for sensitive skin.

Pharmacotherapy A*************c drugsTrusted Source are used against sweating. Unfortunately, these drugs cause a lot of side effects. A*************c drugs are used in hyperhidrosis, mainly affecting many areas of the body, with unsatisfactory results from local therapy. In the treatment of hyperhidrosis accompanied by anxiety and stress, sedative drugs are recommended.

Iontophoresis IontophoresisTrusted Source treatments have found therapeutic applications in treating localized hyperhidrosis, particularly affecting the hands and feet. Iontophoresis involves the introduction of ions into the tissues. A beneficial effect is achieved by closing the sweat gland outlets and inhibiting nerve conduction in the sweat glands. In treating excessive perspiration, iontophoresis is often used; it is non-invasive and has beneficial effects.

B*************n A injections – Sometimes, the methods used, such as topical preparations and iontophoresis, do not have the desired effect. This is when b*************n therapyTrusted Source can be used. A side effect of injection into the skin is the risk of temporary paralysis of the surrounding muscles, which can be particularly troublesome for people performing precision manual work. However, b*************n injections are effective and do not cause a high risk of complications.

Surgical procedures – Hyperhidrosis can also be treated by surgeryTrusted Source, in which a sympathectomy is done. Sympathectomy, nowadays mainly done with an endoscopic technique, involves denervation of the sweat glands by interrupting the sympathetic nerve trunks. As a result, blood vessels in the denervated area of the body are dilated, and sweat secretion is reduced. The effectiveness of this method is very high, but the technique could be more invasive and risky.

Summary

When it’s hot, your body swe­ats to chill. But sweating too much might signal a problem, known as hyperhidrosis. This could be­ all over your body or focus on spots like your underarms, hands, fe­et. Hyperhidrosis has two types. Primary is ge­netic or influenced by your e­nvironment. Secondary is triggere­d by illness or medication.

If you think you might have hype­rhidrosis, a doctor can check. They’ll do lab tests to e­xclude secondary hyperhidrosis. For managing hype­rhidrosis, there are tactics. The­se include skin products, specific me­dications, or other procedures. Se­vere treatme­nt may not be necessary, but se­eing a doctor and undergoing testing he­lps, especially when it gre­atly curbs your life quality.

Sources

January 25, 2024
14 minutes read
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